At the Toxicology division we aim to improve the scientific basis of chemical risk assessment through fundamental and applied innovative research, teaching and training in mechanistic and predictive toxicology. We are looking for an enthusiastic and creative technician to achieve these goals and strengthen our Toxicology Division, which is made up of four research groups: Endocrine-, Immune- and Neuro-toxicology and Exposure Assessment. You will be working on different activities and projects, all focused on improving in vitro toxicity testing. A large part of your work will be performed within in the Neurotoxicology Research Group and will be related to the research project INTACT (abbreviation for: Integrated in vitro toxicokinetics and toxicodynamics to advance multi-organ toxicity testing ) and is in collaboration with the National Institute for Public Health and the Environment (RIVM). INTACT’s goal is to apply and develop innovative models and test methods in the risk assessment of substances for humans without animal tests. To do so, multiple in vitro modules (for example liver, brain, and blood-brain barrier) will be combined to mimic physiological-relevant exposure and kinetics. You will work with various advanced in vitro models (cell lines, primary cells, stem cells) and different culture conditions (2D, 3D, barrier models) to elucidate if environmental chemicals can ultimately reach and affect vital organs leading to adverse effects. Your work will specifically include development and improvement of in vitro models for the brain, the blood-brain-barrier, the heart, the gut and the liver. With these models, you will investigate the potential damage of environmental chemicals using various techniques, ranging from ELISA, PCR, and cell bioassays to cellular imaging (fluorescence microscopy) and microelectrode array recordings. You will support students and (PhD) researchers working on diverse projects that all aim to investigate the potential adverse effects of diverse environmental chemicals. In addition, part of your work will focus on general laboratory duties such as ordering, management of instruments, and maintenance of our electronic lab journal system. We are looking for a colleague with a Bachelor of Applied Science (BASc)/HLOdegree (or equivalent) in the field of life sciences and/or biomedical sciences, with a strong interest in cell biology and toxicology. You have a good verbal and written communication skills in English. Moreover, you are able to work both independently and in our dynamic team. Experience with cell culture techniques is essential. Experience with molecular analysis and cellular imaging techniques is considered a plus. A diploma on animal experimentation (EU function FELASA A+C; ex. art. 13f.2) is an advantage. a temporary positionfor one year, with a possible extension for another year; a working week of32-40 hours and a gross monthly salary between €2,693and €3,636in the case of full-time employment (salary scale 7 under the Collective Labour Agreement for Dutch Universities (CAO NU)); 8% holiday pay and 8.3% year-end bonus; a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU. At the Toxicology division we aim to improve the scientific basis of chemical risk assessment through fundamental and applied innovative research, teaching and training in mechanistic and predictive toxicology. We are looking for an enthusiastic and creative technician to achieve these goals and strengthen our Toxicology Division, which is made up of four research groups: Endocrine-, Immune- and Neuro-toxicology and Exposure Assessment. You will be working on different activities and projects, all focused on improving in vitro toxicity testing. Wat ga je doen?

A large part of your work will be performed within in the Neurotoxicology Research Group and will be related to the research project INTACT (abbreviation for: Integrated in vitro toxicokinetics and toxicodynamics to advance multi-organ toxicity testing ) and is in collaboration with the National Institute for Public Health and the Environment (RIVM). INTACT’s goal is to apply and develop innovative models and test methods in the risk assessment of substances for humans without animal tests. To do so, multiple in vitro modules (for example liver, brain, and blood-brain barrier) will be combined to mimic physiological-relevant exposure and kinetics. You will work with various advanced in vitro models (cell lines, primary cells, stem cells) and different culture conditions (2D, 3D, barrier models) to elucidate if environmental chemicals can ultimately reach and affect vital organs leading to adverse effects. Your work will specifically include development and improvement of in vitro models for the brain, the blood-brain-barrier, the heart, the gut and the liver. With these models, you will investigate the potential damage of environmental chemicals using various techniques, ranging from ELISA, PCR, and cell bioassays to cellular imaging (fluorescence microscopy) and microelectrode array recordings. You will support students and (PhD) researchers working on diverse projects that all aim to investigate the potential adverse effects of diverse environmental chemicals. In addition, part of your work will focus on general laboratory duties such as ordering, management of instruments, and maintenance of our electronic lab journal system. Wat breng je mee?

We are looking for a colleague with a Bachelor of Applied Science (BASc)/HLOdegree (or equivalent) in the field of life sciences and/or biomedical sciences, with a strong interest in cell biology and toxicology. You have a good verbal and written communication skills in English. Moreover, you are able to work both independently and in our dynamic team. Experience with cell culture techniques is essential. Experience with molecular analysis and cellular imaging techniques is considered a plus. A diploma on animal experimentation (EU function FELASA A+C; ex. art. 13f.2) is an advantage. Wat bieden wij?

a temporary positionfor one year, with a possible extension for another year; a working week of32-40 hours and a gross monthly salary between €2,693and €3,636in the case of full-time employment (salary scale 7 under the Collective Labour Agreement for Dutch Universities (CAO NU)); 8% holiday pay and 8.3% year-end bonus; a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU. In addition to the terms of employment externe link

laid down in the CAO NU, Utrecht University has a number of schemes and facilities of its own for employees. This includes schemes facilitating professional development

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, leave schemes and schemes for sports and cultural activities

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, as well as discounts on software and other IT products. We also offer access to additional employee benefits through our Terms of Employment Options Model. In this way, we encourage our employees to continue to invest in their growth. For more information, please visit Working at Utrecht University

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. Over ons

A better future for everyone. This ambition motivates our scientists in executing their leading research and inspiring teaching. At Utrecht University externe link

, the various disciplines collaborate intensively towards major strategic themes

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. Our focus is on Dynamics of Youth, Institutions for Open Societies, Life Sciences and Pathways to Sustainability. Sharing science, shaping tomorrow

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. At the Faculty of Veterinary Medicine externe link

we train the veterinarians and researchers of the future, provide care for animals and conduct leading and societal relevant research. That is what we are good at. We see that the health and welfare of animals, humans and the environment are interconnected. By sharing our knowledge and working together, we make positive impact, both nationally and internationally. Our 1,500 students and 950 staff members inspire and strengthen each other. Our engagement connects us. The drive to, from an integral perspective, make the world a better place. Your position will be in the Toxicology division of the Institute for Risk Assessment Sciences externe link

(IRAS). IRAS is an interfaculty research institute within the faculties Veterinary Medicine, and Medicine. Our mission is to provide education and research on the human and environmental health risks of exposure to potentially harmful agents in the environment where research takes places within the domains Toxicology, Environmental Epidemiology and Veterinary Public Health. Meer informatie

For more information, please contact Dr Remco Westerink externe link

atr.westerink@uu.nl . Please do not send your application to this email address. Sollicitatie

As Utrecht University, we want to be a home externe link

for everyone. We value staff with diverse backgrounds, perspectives and identities, including cultural, religious or ethnic background, gender, sexual orientation, disability or age. We strive to create a safe and inclusive environment in which everyone can flourish and contribute. To apply, please send your curriculum vitae, including a letter of motivation, via the ‘apply now’ button.

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